Thomas N Seyfried Selected Research

G(M2) Ganglioside (Ganglioside GM2)

5/2015	Bis(monoacylglycero)phosphate: a secondary storage lipid in the gangliosidoses.
3/2015	AAV-mediated gene delivery in a feline model of Sandhoff disease corrects lysosomal storage in the central nervous system.
6/2010	Restricted ketogenic diet enhances the therapeutic action of N-butyldeoxynojirimycin towards brain GM2 accumulation in adult Sandhoff disease mice.
3/2009	Comparative analysis of brain lipids in mice, cats, and humans with Sandhoff disease.
5/2008	N-butyldeoxygalactonojirimycin reduces brain ganglioside and GM2 content in neonatal Sandhoff disease mice.
5/2006	Influence of caloric restriction on motor behavior, longevity, and brain lipid composition in Sandhoff disease mice.

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Thomas N Seyfried Research Topics

Disease

45	Neoplasms (Cancer) 01/2023 - 08/2004
19	Brain Neoplasms (Brain Tumor) 01/2018 - 08/2004
11	Sandhoff Disease (Sandhoff's Disease) 11/2023 - 05/2006
11	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2022 - 08/2004
11	Astrocytoma (Pilocytic Astrocytoma) 01/2020 - 10/2005
10	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 04/2010
8	Hypoxia (Hypoxemia) 01/2024 - 09/2006
8	Neoplasm Metastasis (Metastasis) 08/2022 - 05/2008
8	Body Weight (Weight, Body) 01/2022 - 05/2004
5	GM1 Gangliosidosis (Gangliosidosis GM1) 01/2022 - 05/2004
5	Gangliosidoses (Gangliosidosis) 09/2015 - 04/2007
5	Epilepsy (Aura) 09/2014 - 08/2003
4	Breast Neoplasms (Breast Cancer) 04/2021 - 01/2020
4	Inflammation (Inflammations) 12/2020 - 01/2015
4	Seizures (Absence Seizure) 01/2020 - 08/2003
4	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2015 - 05/2004
3	Ketosis 10/2023 - 01/2020
3	Disease Progression 08/2022 - 01/2018
3	Mitochondrial Diseases (Mitochondrial Disease) 05/2017 - 11/2008
2	GM2 Gangliosidoses (GM2 Gangliosidosis) 11/2023 - 01/2014
2	Ductal Carcinoma 04/2021 - 07/2017
2	Hyperthermia 04/2021 - 07/2017
2	Huntington Disease (Huntington's Disease) 11/2010 - 09/2007
2	Drug Resistant Epilepsy 04/2010 - 06/2009
2	Glioma (Gliomas) 10/2008 - 02/2007
2	Sudden Death 08/2004 - 01/2003
1	Lung Neoplasms (Lung Cancer) 08/2022
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 08/2022

Drug/Important Bio-Agent (IBA)

31	Glucose (Dextrose)FDA LinkGeneric 10/2023 - 08/2003
15	Ketone BodiesIBA 08/2021 - 08/2003
15	LipidsIBA 11/2016 - 05/2006
14	Glutamine (L-Glutamine)FDA Link 08/2021 - 11/2010
10	GangliosidesIBA 05/2015 - 05/2004
9	KetonesIBA 01/2021 - 02/2007
8	GlycosphingolipidsIBA 01/2015 - 05/2004
6	G(M2) Ganglioside (Ganglioside GM2)IBA 05/2015 - 05/2006
5	Oxygen (Dioxygen)IBA 01/2024 - 08/2004
5	EnzymesIBA 11/2023 - 05/2004
5	CarbohydratesIBA 01/2023 - 02/2007
5	Lactic Acid (Lactate)FDA LinkGeneric 01/2022 - 12/2015
5	Proteins (Proteins, Gene)FDA Link 11/2016 - 05/2008
4	Adenosine Triphosphate (ATP)IBA 01/2022 - 11/2020
4	GalactosidasesIBA 01/2022 - 10/2010
4	Blood Glucose (Blood Sugar)IBA 01/2015 - 10/2004
4	beta-N-AcetylhexosaminidasesIBA 06/2010 - 07/2007
4	3-Hydroxybutyric Acid (beta-Hydroxybutyric Acid)IBA 02/2007 - 10/2004
3	Glutamic Acid (Glutamate)FDA Link 01/2024 - 01/2018
3	Succinic Acid (Succinate)IBA 01/2024 - 01/2018
3	Insulin (Novolin)FDA Link 10/2023 - 01/2018
3	Pyruvate KinaseIBA 08/2021 - 12/2008
3	Biomarkers (Surrogate Marker)IBA 01/2021 - 05/2008
3	Anticonvulsants (Antiepileptic Drugs)IBA 01/2020 - 10/2004
3	Triglycerides (Triacylglycerol)IBA 01/2018 - 01/2014
3	Hexosaminidases (Hexosaminidase)IBA 05/2015 - 05/2006
3	Firefly LuciferasesIBA 01/2013 - 01/2010
2	Oxidoreductases (Dehydrogenase)IBA 01/2024 - 02/2007
2	succinyl-coenzyme A (succinyl-CoA)IBA 01/2024 - 02/2007
2	SteroidsIBA 01/2023 - 01/2022
2	Fatty Acids (Saturated Fatty Acids)IBA 01/2020 - 05/2015
2	AcidsIBA 01/2020 - 10/2010
2	Temozolomide (Temodar)FDA LinkGeneric 01/2018 - 04/2010
2	CholesterolIBA 12/2015 - 07/2011
2	Phospholipids (Phosphatides)FDA LinkGeneric 09/2015 - 07/2008
2	G(M1) GangliosideIBA 01/2015 - 08/2004
2	Cardiolipins (Cardiolipin)IBA 01/2014 - 12/2008
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2012 - 09/2006
2	chondroitin sulfate proteoglycan 4IBA 08/2010 - 05/2008
2	G(M3) GangliosideIBA 01/2010 - 09/2006
2	Therapeutic UsesIBA 11/2008 - 02/2007
2	migalastatIBA 05/2008 - 05/2004
2	acid beta-galactosidaseIBA 08/2004 - 05/2004
1	Ketoglutarate Dehydrogenase Complex (Oxoglutarate Dehydrogenase)IBA 01/2024
1	NAD (NADH)IBA 01/2024
1	UbiquinoneIBA 01/2024
1	QuinonesIBA 01/2024
1	Plasminogen Activator Inhibitor 1IBA 10/2023
1	A 7 (A-7)IBA 01/2023
1	oligomycin sensitivity-conferring protein (complex V)IBA 01/2023
1	OilsIBA 01/2023
1	Waste Products (Waste Product)IBA 01/2022
1	Pyruvic Acid (Pyruvate)IBA 12/2021
1	Cyanides (Isocyanides)IBA 08/2021
1	2-methylcyclopentadienyl manganese tricarbonyl (MMT)IBA 08/2021
1	NitrogenIBA 08/2021
1	Protein Isoforms (Isoforms)IBA 08/2021
1	Melanins (Melanin)IBA 06/2021
1	Progesterone Receptors (Progesterone Receptor)IBA 04/2021
1	human ERBB2 proteinIBA 04/2021
1	Estrogen ReceptorsIBA 04/2021
1	AntibodiesIBA 01/2021

Therapy/Procedure

41	Therapeutics 01/2023 - 05/2004
23	Ketogenic Diet 01/2023 - 01/2003
8	Drug Therapy (Chemotherapy) 08/2022 - 04/2010
6	Diet Therapy (Therapy, Diet) 01/2012 - 08/2004
5	Caloric Restriction 03/2011 - 08/2003
4	Hyperbaric Oxygenation 04/2021 - 01/2013
2	Carbohydrate-Restricted Diet (Low Carbohydrate Diet) 08/2022 - 06/2009
2	Radiotherapy 08/2022 - 04/2010
1	Lasers (Laser) 06/2021
1	Biological Therapy 04/2021